Nature of the Traffic Safety Problem in Oman

Nature of the Traffic Safety Problem in Oman Introduction The focus of this paper is to clarify, elaborate and organize emerging perspectives of problem definition. Particular aims are: analysis of malleable nature involving public cases based on the problem definition, determination of common kinds of problem definition as such description posse powerful impacts for policy design and agenda access.Advertising We will write a custom case study sample on Nature of the Traffic Safety Problem in Oman specifically for you for only $16.05 $11/page Learn More In addition, the treatise aims to provide myriad illustrations of persuasive importance of problem definition within political contemporary context. Also, form strategy of investigation, ramification, and elements of the problem definition are addressed. Nature of the traffic safety problem in Oman The analysis of social reality shows that problem definition refers to a political claim which provides solution to such vital policy inquiry. The main aim i s to delineate key problem descriptions with their options. Nature of social problem embraces several dimensions that go beyond causality. Such features may reduce or enhance opportunities of public acts. Problem nature may be analyzed in terms of severity, crisis, novelty, incidence and proximity. Severity is how serious a challenge and its impacts are. For example, if an issue encounters trouble of pubic crowd, magnitude of people will affect public agenda. On the other side, devastating effects of little population may also contribute to a persistent problem. How severity is strong may be a contentious issue because such problem definition is crucial in capturing agenda of the media and public official. Incidence of social problem is a vital dimension which represents affected people such as groups in trouble. Incidence is a debatable issue which intermix existing information and politics. In some cases, the issue is likely to change with time. A problem may be stable, develop, o r decline. Exponential and linear projections are commonly ominous. If accepted to be valid, then it may build intense pressure that is suitable for faster public intervention (Smith Larimer 67-68). New projection of such kind captures space in daily newspapers. For example, troubling forecast on global deforestation, surging traffic challenge experienced in New York due to increased quantity of vehicles’ registration, and issue of declining trends of airline safety are just but a few. Incidence cases have social dimensions that affect human society such as child abuse and poverty issues.Advertising Looking for case study on political sciences? Let's see if we can help you! Get your first paper with 15% OFF Learn More Novelty issue is a trailblazing, unprecedented or novel whose effects draw attention. After some time, a novel issue many wane, and media or public get bored with the matter and thus withdrawn from it. Matters that have never been witnes sed are not easy to be conceptualized since they don’t have familiar resolutions from people. Therefore, when tension emerges, it may be publicized while people expect solution from it, though no consensus may be reached by political system to solve the challenge (Shahalam, 23-24). For example, new drug may be promising to treat serious health challenges like HIV-AIDS. People may be pleased with such invention. However, the drug, that is beneficial, may be risky thus have to be assessed carefully. Critics may encounter such as time consuming and problematic. Every invention that brings practical and ethical significance needs evaluation. Proximity may be illustrated in this debate when an issue impinges interests of an individual(s) within his/her or their locality. Proximity may capture people’s attention and may be expressed politically. The matter’s proponents attempt to promote their base due to individual relevance. Consequently, National Commission; which is concerned with child affairs, unveiled its report based on child poverty in United States. It describes such problem as personal tragedy and also as country’s strategy. Crisis is an aspect that is applied in a condition where resolution is overdue for long time and dire situation persist. National deficit is an issue that is associated with crisis. Death cases in 1986 of two famous athletes due to drug overdose together with emergence of new kind of cocaine changed the drug problem into crisis situation. Emergency is a concept synonymously utilized with crisis (Rochefort Cobb 56-71). Problem of homelessness may define a condition as emergent that needs quick response to provide temporary solutions (shelter provision) instead of long-term comprehensive reforms associated with health care, housing and unemployment. Cause of traffic safety problem in Oman Problem causation defines the origin of the problem. Vital distinction is to determine whether a challenge is impersonal or individual cause. For example, underclass challenge may be attributed to either cultural and economical systems or lack of personal determination. In technological realm, (for example), equipment error or human duties may accounts for failure of Nuclear Plants.Advertising We will write a custom case study sample on Nature of the Traffic Safety Problem in Oman specifically for you for only $16.05 $11/page Learn More Perception of causation is likely to be ingrained in human propensity. When something happens, immediate action is to examine underlying justifications as to why such event occurred. Accidental and intended causes are distinct to one another. Intended causes are human act purposively formed to bring specific impacts. According to public making policy, when an action is thought to be victorious, then it is rational. But if it is not successful, such failure sources are linked to conspiracies. Some problems are simple and particular to a single cause. Others have various influences. Problem definitions based on two ways may predispose political action into various impacts. Channeling the aim into either two or one casual factor(s) is an indication that those who define the problem are willing to make immediate response. More complex policies may be formed to promote prompt response. Policy makers may make foolish interventions when overwhelmed with inadequate knowledge of casual interaction. However, there exist vital exceptions to such common system. Policy makers may engender multi-pronged resolutions and multi-casual justifications among sophisticated attempts and those that posses great capability to create effective support. Catastrophic of crude oil in Alaska is a good experience that counsels the society not to concentrate on personal scapegoats but rather to enhance mechanisms of cleanup and prevention of oil spill including other measurers such as faster spill response strategy and effective tanker design. Charact eristics of the problem population Such problems are individuals and groups problems. This happens in social welfare whose aim intends to provide services and resources to particular target populations. Political interests to execute such determinations depend on the societal views of people who will benefit (Baumgartner and Jones, 2-11). Balance between coercion and assistance based on policy designed depends on how negative or positive such perceptions are.These are vital dimensions for government‘s policy, because any attitudinal axes support to form aggregate impression If a community is unworthy or worthy to get support. Out-group (out-law) individuals and deviants’ members may not get similar consideration to people who have shown public willingness and responsilibity. Threatening and sympathetic populations should be evaluated in the similar way. Such attributes may be used to account for mentally ill, elderly, poor and working persons.Advertising Looking for case study on political sciences? Let's see if we can help you! Get your first paper with 15% OFF Learn More Data of public opinion may also demonstrate favorable attitude of various claimants to be given support in such a society. Current public policy contracts this move. It claims that it is not wise to use restrict resources in supporting disliked or silent people or sex offenders. In fact, States have to provide more for social aide to the AIDS and elderly and disadvantaged victims. Abusers should not be seen as unfortunate people in society. They should be supported without biasness. Possible policy solutions Definitional attempts in policy making develop from problem issues to those who are interested in and influenced by such to involve solution descriptions toward alleviating such challenges. Unless political harmony crystallizes such issues, government may not implement such. This policy emphasizes projective, empirical and scientific matters to assist in determining the impacts and likelihood to obtain desirable outcomems. The most key focus at this level is to generate effectiv e solutions. It is either worse or good impacts of political realm, a nostrum which have not been evaluated and applied in macro-social level. Thus, policy makers only engage in skepticism (guessing game) to choose either restraint or aggressive intervention. This has influenced economic events with important strategies in experienced touted resolutions whose reliabilities are controversial. For example, Nuclear Plants intends to provide reliable and cheap electricity, health programs is focused to enhance better living standards, training and employments aims to counteract dependency level, and recycling process attempts resolve disposal challenge. All these are faced with controversy due to skepticism. Acceptable solution is not an effective action but has to be an act that conforms to an acceptable standard behavior. This is an ethical issue, though it is faced with controversy. For example, Chemical Warfare was brought by war experience in Middle East region. Such weapons were l ethal not only to the targeted enemies but also to military arsenals who used them. Owning lethal weaponry is not acceptable because it is harmful. Acceptability is an ethical issue that enhances new technology. Though, fetal tissue implantation is important in combating nervous problem in human life, it is opposed because such surgery may enhance abortion. It may be implanted in the person’s brain who suffers from Parkinson disease. Policy intervention may be available, agreed and acceptable, but its affordability raises many inquiries. For instance, Policy makers are careful in carrying out financial tasks. People’s demands are increasing with new and existing programs. A funding has provided positive social and education impacts to disadvantaged preschool aged children (Anderson, 45). There is controversy about how much should be funded to serve all children who are eligible. The country is also determined to improve infant mortality, though prenatal service is comp lex and expensive. It is controversial how all such services will be delivered, particularly through which way of funding. Affordability invokes different standards of aims of participants. Finance comparison with various proposed policies, depending on cost estimates and budgetary constraints compared with social and economic costs of failure to act are prevalent. Conclusively, problem definition remains a fundamental aspect in public making policy. It is a political process in enacting legislation, initiation and program design. This paper examines the impacts, origin and elements of problem definition linking this attempt to recent policy enacting progress and future investigation needs. Pubic making policy is based on logical natural consequence. Social problems may be solved through gathering information. Public officials should assess the causes of the problem and to provide solution by effectively enacting new legislation. The strategy is carried out until the challenge is re solved. Empirical proof refutes such claim. This explains that other factors, a part from objective situations, are responsible to particular challenges. Arbitrariness and controversy may affect how a situation is understood. There exist divergent views of significance, origin and effects of any challenge in the communal context. Language usage is critical in analyzing what aspect of any challenge to be evaluated. Anderson, James. Public Policy Making, New York: Wadsworth / Cengage, 2011. Print. Baumgartner, Frank R. and Bryan D. Jones. Agenda and Instabilities in American Politics. Chicago: University Chicago Press, 2009. Print. Rochefort, David and Roger W. Cobb. ‘‘Problem Definition, Agenda Access and Policy Choice.’’ Policy Studies Journal 21.1(1993): 56-71. Print. Shahalam, A, et. al. ‘‘Oman Traffic Safety Case: Traffic Accidents and Potential Causes.’’ National Engineering Conference on Roads 5(2001): 23-24. Print. Smith, Ke lvin B. and Christopher Larimer. The public policy theory primer. Bouldre: West View Press, 2009. Print.

Incite, Incentive, Incent, Incentivize

Incite, Incentive, Incent, Incentivize Incite, Incentive, Incent, Incentivize Incite, Incentive, Incent, Incentivize By Maeve Maddox The first two words in the title, incite and incentive, have been in the language a long time: incite (1483) verb: to urge or spur on incentive (1475) noun: something that arouses feeling or incites to action. The verbs incent and incentivize are later arrivals that currently offend the sensibilities of many speakers: Some neologisms deserve to be throttled, wrapped up in black plastic, and dropped into the deepest crevices of the  Marianas Trench as soon as they are created. Two such words are  incent  and  incentivize. –Writing, Clear and Simple (2007) Does it bug you when you hear a word that’s not really a word–Take this example: incent. I hear this all the time, especially in business. As in, â€Å"What can we do to incent our staff to work harder?† –Edit This Blog (2011) You receive incentives to incentivize you. What do you get when youre incented? Incents? Incention?–Commenter reacting to another reader’s defense of incent. The verb incent, a backformation of the noun incentive, has an OED entry that documents the forms incented and incenting, but none for plain incent. The earliest citation is from 1844: â€Å"Incented by the stupid ambition of an ignorant mother, she thought that the purse of the one was far superior to the heart of the other.† The most recent (1997) identifies incent as not quite standard by enclosing it in quotations: â€Å"Workers need to be ‘incented’ with bonuses, stock options, and dispersed decision-making.† The verb incentivize first appears on the Ngram Viewer in the late 1950s, but doesn’t make much of a showing until the 1980s, when it begins to soar. Since then it has become a staple of business vocabulary. How can health plans incentivize members to take care of their health? Use objective measures to incentivize midlevel providers for increased productivity. FDA outlines plan to incentivize high-quality manufacturing. All of the words in this group derive from Latin incendÄ•re, â€Å"to kindle, set on fire.† An incentive is something that provokes a person to action. â€Å"Incentive pay† is documented from 1943. The noun incentive in the sense of payment to encourage a worker dates from 1948. Some readers object to both incent and incentivize, preferring the phrase â€Å"offer incentives to,† or the verb motivate. Others reject incent, but accept incentivize, arguing that motivate does not have quite the same meaning: There really is a difference between incentives and motivation. What an incentive is â€Å"I am going to pay you to want what I want.† And as long as you pay people to want what you want they do it. The minute you stop paying them to want what you want, they stop. And they are not motivated to do anything. They were just incentivized to do just that. –Clayton Christensen, BBC InBiz podcast, September 6, 2012. Regardless of one’s aversion to the sound of incentivize, railing against it is futile. When a new word is perceived as filling a gap, it will prevail. Incentivize is here to stay, right along with amortize, alphabetize, anesthetize, burglarize, commercialize and all the other -ize verbs we may or may not find pleasing to the ear. Incent, on the other hand, is supremely expendable. For one thing, it is used with the same meaning as incentivize. For another, the sound is so close to incite and incense as to invite misunderstanding. Incite can be used with a neutral meaning, for example, â€Å"to incite interest,† but is usually used in the context of stirring up trouble, as in â€Å"to incite violence.† The verb incense (accent on the second syllable) means, â€Å"to provoke to anger,† as in â€Å"Failure to abide by these requirements could incense an already emotional worker and trigger unnecessary and irksome litigation.† An inattentive listener might misunderstand the motives of an employer who wants â€Å"to incent his workers.† At present, incite isn’t so much as a speck on the Ngram Viewer so it may not be too difficult to ignore it into oblivion. As for incentivize, speakers who can’t bear to utter the word have options: prompt drive motivate inspire stimulate influence encourage offer incentives bribe Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Misused Words category, check our popular posts, or choose a related post below:16 Substitutes for â€Å"Because† or â€Å"Because Of†List of Greek Words in the English Language50 Synonyms for "Song"

Concept Analysis Research Paper Example | Topics and Well Written Essays - 1500 words

Concept Analysis - Research Paper Example These instructions provide patients with critical information on how to manage themselves in terms of medication, diet and which symptoms should prompt the patient to return back (Lee & Bokovoy, 2005). Issuing of discharge instructions to patients is a key requirement of health care facilities by the health accreditation institutions such as the Joint Commission on Accreditation of Healthcare Organizations-JCAHO (JCAHO, 2007). Despite holding to this requirement, it is widely reported that patients fail to comprehend or remember the discharge instructions. This is contributed by both parties: practitioners failing to elaborate clearly the instructions and patients failing to follow the instructions. This paper is a concept of comprehension that focuses on discharge instructions and how patient’s comprehension of these instructions affects their outcome. Concept of Comprehension on Discharge Instructions Discharge instructions refer to instructions given to patients upon discha rge from hospital. These instructions detail diagnostic information and measures to be taken. As noted by Forster et al. (2004) close to a quarter of patients discharged experienced adverse cases in a span of one month. These events were medication errors, orders/prescriptions filling, confusing discharge instructions, neglect of following unresolved cases and infections. Some of these effects were preventable whereas others called for further treatment probably half of the effects. Moreover, Forster et al asserted that a third of the events were linked with disability (Forster et al., 2004). According to Zavala et al. (2011) 78 percent of discharged patients from emergency department failed to fully comprehend the discharge instructions. However, 20 percent acknowledged they did not understand the discharge instructions. This was achieved from a study conducted in a healthcare facility in Virginia, Reston Hospital Center. This study focused to reach the discharged patients from the facility in order to get their understanding of discharge instructions and its effect. A fifth of the patients interviewed did not understand the discharge instructions based on the medicine described. Additional 9 patients reported worsened and continued symptoms where they were reminded to follow up treatment. A few patients reported their discomfort about the discharge instructions and some did not receive the discharge instructions (Zavala et al., 2011). Understanding as well as memorizing discharge instructions is very challenging. This is associated with several aspects such as discomfort and literacy levels. Relative to discomfort, patients and their surrogates are filled with various discomforts emotionally and physically. More specifically, patients and their surrogates are filled with excitement of leaving hospital. This carries away their attention and thus they are less concerned about the discharge instructions. Additionally, the busy hospital environment during discha rge also causes discomfort to the patient/patient surrogates and distracts their attention to discharge instruction. In such a situation, the busy physicians assume patients understand the instructions and to further complement this health brochures are given. Majority of patients obtain and understand little of these information from the health brochures. This creates great disparity between the reading and literacy level

Linguistic Analysis Essay Example | Topics and Well Written Essays - 1750 words

Linguistic Analysis - Essay Example An analysis of the underlying lexicogrammatical signatures within linguistic corpora(Gilquin et al, 2007: 322) is facilitated through error tagging systems. One example of an error tagging system that is devised by Nicholls is a three-tier system specifying the error domain (the form, grammar, lexis, etc), the category of the error (for instance, whether tense, gender or number) and the word category (adjective, noun, verb, etc), which offers tremendous potential in teaching of English as a foreign language. One of the findings that has emerged from learner corpora is that some linguistic features are common to learners from all foreign language groups, which may be developmental, while some appear characteristic of particular linguistic groups. Riney and Takagi (1999), have highlighted the results of various studies that have examined the correlation between global foreign accent and voice onset time in Japanese EFL speakers. One of the findings was that VOT did not change over time in Japanese speakers of English, suggesting that there may be a phonological similarity between Japanese and English diaphones. While voice onset time might be similar, however, the specific pronunciation of some of the words reveals the distinct differences arising as a result of differences in dialect. Carter and McCarthy(2006) offer the view that spoken grammars have uniquely special qualities that distinguish them from written grammar and these are sometimes elements perceived to be errors in written speech.

N. Fowleri Diagnosis, Treatment and Prevention

N. Fowleri Diagnosis, Treatment and Prevention Historical Aspect: Naegleria Fowleri (N. Fowleri ) is a free living, thermophilic protozoan that is a human specific pathogen that attacks the central nervous system. It can be found in contaminated freshwater sources. It enters through the nose and travels to the brain causing primary amoebic meningoencephalitis1. It was first observed in 1899 and later named after Dr. M. Fowler, who observed the first reported fatal cases of acute pyogenic meningitis in Australia in 19652. While these infections have been identified as early as the 19th century it is challenging to identify because it mimics many of the symptoms of bacterial meningitis[1]. Primary amoebic meningoencephalitis (PAM) is a necrotizing and hemorrhagic meningoencephalitis3. The symptoms begin 1-9 days after the onset of infection these symptoms include fever, nausea, headache and vomiting. The initial symptoms mimic those of bacterial meningitis, the later symptoms are unique to this disease. Later symptoms include neck stiffness, hallucinations, seizures, an inability to focus, lack of balance and eventually coma and death. The mortality rate for this disease is 95%. The disease progresses quickly and leads to death within 12 days of the initial infection1. While this infection has a high mortality rate, it is very rare. There have been 300 reported cases of PAM worldwide in the last 40 years4. It is important to note that this conditioned is often misdiagnosed so these numbers are estimates. In the United States there have been 138 cases in the last 50 years1. This infection was once a condition that plagued developing countries but the incidence is spreading all over the world. Researchers suspect that the increased temperatures due to global warming, increased use of public water sources due to scarcity and an overall increase in aquatic recreational activities are to blame3,18. While swimming and other aquatic recreational activities help proliferate this disease so do rituals. Aga Khan University in Pakistan noticed an increased number of deaths caused by PAM in young males that had no history of swimming, but were devout Muslims. Those who practice this faith pray five times a day and before every prayer, they perform ablution, ablution is the washing of the hands, face, ears, nose, mouth, arms and feet. While cleansing the nose, water is forced up the nose putting individuals performing this practice with inadequately purified water at a greater risk for PAM3. Religious festivals like the Kumbh Mela where Hindus gather and swim in the Ganges river put those who participate at risk of developing diseases like PAM caused by N. Fowleri 3. In addition to religious practices, therapeutic interventions like the Neti pot increase the risk of PAM. Nasal irrigation systems like the Neti pot work to relieve the symptoms of sinusitis and cold. It works by removing debris and mucus from the nasal passages. The recommendation is that the water should be boiled or mixed with a non-ionized sodium chloride. Basic structure: N. Fowleri are a part of the free living amoeba that cause infections in the central nervous system. Some of the other protists are Acanthamoeba spp and Balamuthia mandrillas. Naegleria fowleri have been classified by modern techniques which analyze morphology, biochemical pathway and molecular phylogeny2. The modern approach classifies N. Fowleri as a part of the super group Excavata, in the group Heterolobosea and a part of the family Vahlkampfiidae. Although the genome for N. Fowleri is not yet completed there are some studies producing information about its molecular and genetic characteristics. N. Fowleri s genus includes more than 40 species, but N. Fowleri is the only one that is known to cause disease in humans. De Jonckheere created the most popular identification system for N. Fowleri . The identification system uses genetic markers like internal transcribed spacers (ITS1) and 5.8S rDNA 2. This identification system revealed at least 8 different genotypes. The genotypes are dispersed among different continents America (I,II,III), Europe (III,IV,V,VI,VIII), Oceania (V), and Asia (II,III). Of the eight genotypes only four have been found in humans, types 1-42. Naegleria are a part of the group heteroloboseans that have a three-phased lifecycle. They are first amoeba, then flagellate and lastly cyst formation5. N. Fowleri reproduces in the amoeba form via binary fission to produce the cyst and the flagellate forms. The entire cell cycle is 8 hours, N. Fowleri spends 28 minutes in M phase, 180 minutes in G1, 183 minutes in S phase, and 90 minutes in G22. In the amoeba form, the trophozoite ranges in size from 15-25 Â µm. Trophozoites also have cytoplasmic projections called food cups which allow phagocytosis of bacteria, yeast, erythrocytes and cellular waste. Trophozoites are the form of the amoeba that can feed and divide, they are also the form that enter the human host6.Trophozoites will transition into the flagellate stage after being exposed to a saline solution2. The flagellates cannot feed or divide, the transition also involves a change in shape from pleomorphic to pear shaped with a pair of flagella. The flagella have the typical 9+2 structure and are surrounded by a cytoplasmic membrane. The 9+2 flagella structure describes the cross- sectional arrangement of microtubules that make up the flagella. There are nine doublet outer tubules and two central singlet tubules7. The cyst form is resistant to most disinfection. The cyst formation is spherical, smooth, double walled and refractive. They measure about 20Â µm. The material of the cyst wall is synthesized and packaged by the rough endoplasmic reticulum2. Route of Transmission: N. Fowleri is a thermophilic amoeba, its optimal temperature ranges from 1150 to 1220 F. N. Fowleri can typically be found in warm freshwater like lakes and rivers, warm water from industrial parks, or inadequately chemically treated water, other warm water sources like water heaters and soil. In their natural environment N.Fowleri phagocytize cyanobacteria and eubacteria to regulate levels. Samples from the lakes of the southern United States reveal that N. Fowleri introphozoite formis present during the summer. During the winter months N. Fowleri in cyst form survive in freshwater sources, but no form of N. Fowleri can withstand freezing temperatures1 . Most cases of PAM are caused by swimming in warm freshwater, from drinking water, recreational activities, ritual abulation and sinus irrigation systems1. Infection occurs when water containing N. Fowleri gets into the nose. The amoeba enters the nose and travels along the olfactory nerve, through a bony plate in the skull called the cribriform plate3. Once it reaches the brain it causes meningoencephalitis, cerebral edema and results in herniation. The olfactory bulbs and orbitofrontal cortices become necrotic and hemorrhagic. The data on both humans and mice support the conclusion that death is ultimately caused by increased intracranial pressure and herniation3. Swimming in water containing N. Fowleri increases the risk for PAM but age and sex are also risk factors. From the 1962- 2015 there have been 138 reported cases of PAM in the United States, 114 of the cases have been children around the age of 12. Nearly 75% of the infections have affected males1. Certain behaviors are associated with an increased risk of infection, those infected individuals reported participating in water related activities like swimming, diving and head dunking1. Although N. Fowleri can be transmitted through water it cannot be transmitted through aerosols or droplets, or via person to person contact. N. Fowleri can be found in other organs of the body, such as the heart, lung, spleen and thyroid1. Pathogenesis: N. Fowleri enter the human host through the nose which provides access to the brain. Within eight hours of infection N. Fowleri is present in the mucus layer of the olfactory epithelium. Within 24 hours N. Fowleri are in the olfactory bulb and present in the cribriform plate. By 96 hours neutrophil polymorphs cause a severe inflammatory response in the olfactory bulb which leads to brain tissue damage3. Contact dependent mechanisms are N. Fowleri mediated pathogenic processes. The primary mechanism of pathogenesis in N. Fowleri is adhesion. Adhesion allows for movement and chemotaxis in the nasal mucosa and assists N. Fowleri with disease progression. Adhesins are expressed on the surface of N. Fowleri, the adhesins are integrin like proteins surrounded by adhesion like structures. Fibronectin binding protein, protein kinase C and NFa1 are important to interrupting the host mediated cytotoxicity3. In an experiment testing cytopathicity of N. Fowleri, a culture would bind to Fibronectin and in the presence protein kinase C the ability of the amoeba to adhere increased8. N. Fowleri also produces Reactive Oxygen Species (ROS) which damage the host cell. Following cell damage, N. Fowleri uses phagocytosis and amoebastomes to assist N. Fowleri in breaking down and consuming the cells through a sucker structure on its surface. These processes are mediated via actin and involve the polymer ization of monomeric G-actin and filamentous F-actin. Studies have found that a membrane protein Mp2CL5 may also play a role in pathogenicity, without this protein N.Fowleri are nonpathogenic3 .This protein is suspected to aid in pathogenicity by navigating the environment, and movement toward food sources9. In addition to contact dependent mechanisms of pathogenicity, N.Fowleri also utilizes contact independent mechanisms. N-PFP is a cytolytic pore forming protein that depolarizes the cell membrane and decreases the integrity. Naegleriapores A and B are pore forming polypeptides that are very similar in structure and function. Both are antimicrobial and cytolytic polypeptides3. The enzymes phospholipase A, A 2 and C are present in patients with PAM. Phospholipases are responsible for the demyelination of white matter. Sphingomyelinase, neuroaminidase, elastase and proteolytic enzymes are responsible for demyelinating nerve tissue. N. Fowleri are hemolytic due to the heat shock protein 70 which is unaffected by salt concentrations, chelating agents, pH and temperature extremes3,10. This protein is present in the cytoplasm, pseudopodia and phagocytic food cups. There are many other factors associated with the pathogenicity of N. Fowleri and others that are suspected to have an effect on t he pathogenicity. On the onset of infection the hosts innate immune system attempts to reduce the pathogens cytotoxicity. During the early infection the body releases mucin which surrounds the N.Fowleri trophozoites to prevent cytotoxicity. In the later infection eosinophils and neutrophils surround the N. Fowleri cells to prevent cytotoxicity. Inflammation increases over time, although there are not many cells that penetrate the host epithelium. The inflammation and polymorph nuclear cells from the host response damage cerebral tissue2 . Diagnosis, Treatment, Prevention: Diagnosis of N. Fowleri is heavily dependent on laboratory techniques. The most effective way to diagnose N. Fowleri requires cerebrospinal fluid (csf) which is conducted while the patient is living and brain biopsy which is conducted post-mortem11. Different laboratory tests are utilized to analyze the specimen. When PAM is suspected, samples can be wet mounted and placed under a microscope to identify trophozoites12. Polymerase chain reaction is a method that can be used to amplify DNA, to identify the presence of N. Fowleri DNA in a sample11. Another laboratory technique involves antigens that were developed from mouse monoclonal antibodies (mAbs) against N. Fowleri . When indirect immunofluorescence assays are used mAbs react to N.Fowleri from specific geographic regions13. The infection due to PAM progresses quickly and as previously stated, mimics symptoms of bacterial meningitis. Even with the advances in laboratory diagnostics most cases are diagnosed post mortem making effective treatment elusive. One successful case study provides an example of effective diagnosis and treatment of this condition. On July 13, 2013, a 12 year-old girl presented to Arkansas Childrens Hospital vomiting, having trouble holding up her head and was unable to open her eyes. A few days prior to hospitalization the patient had been playing in a local water park. During her hospitalization she experienced hallucinations, and thirst. A spinal tap was performed which ruled out bacterial meningitis. The laboratory identified N. Fowleri trophozoites in the patients cerebrospinal fluid. After determining the infection was PAM caused by N. Fowleri, physicians initially treated the patient with antibiotics and antifungals like Amphotericin B, Rifampin, Fluconazole, Dexamethasone an d Azithromycin .None of these treatments improved the condition of the patient. The hospital petitioned the Center for Disease Control (CDC) to allow the use of a new experimental drug available for the treatment of N.Fowleri14. The drug Miltesfosine was given 36 hours after the initial diagnosis, physicians also lowered the patients body temperature to 93.2 F0 to reduce cerebral edema and intracranial pressure. After 18 days in the ICU there was no N. Fowleri found in her system. The patient experienced a full but gradual recovery over the next fifty five days. After seven days the patient was able to write her name, in fourteen days she was able to speak in one and two syllable words. She also underwent both speech and physical therapy14. This patient is one of the three known survivors of PAM. While the virulence factors and the degree of recovery that surround the other two cases of survival are unknown. The prompt diagnosis, treatment with Miltesfosine within thirty six hours and maintaining a low body temperature for this patient played significant roles in effectively treating this infection14. Although the first case of N. Fowleri was over 50 years ago, the mortality rate for this disease continues to increase due to water scarcity which increases use of water from public sources. As previously stated this condition is either diagnosed post mortem or misdiagnosed. The development of a standard microbial treatment will aid in the reduction of high mortality rates14. In the three cases of survival the patients were all intially treated with amphotericin B, rifampcin, fluconazole, dexamethasone and phenytoin during the first week of infection15. In 1969 a patient survived PAM with the successful treatment of amphotericin B. The patient in 2013 was initially treated with amphotericin B and it was ineffective. Miltesfosine effectively treated this patients PAM14. Other drugs with the potential to treat PAM have been tested, and some have been proven effective while others have not. Clotrimazole a drug that has been used as an antifungal had potential to treat PAM but under further study was deemed ineffective16. In developing countries like Pakistan where water is in short supply and ablution is common practice the danger of becoming infected with N. Fowleri is greatly increased. Water sources in these countries include wells or water storage tanks which are often contaminated with N. Fowleri 17. In order to prevent infection the World Health Organization (WHO) encourages that water storage units and wells be regularly tested to ensure proper disinfection. Public health organizations have also encouraged the use of nose clips while swimming in lakes and other freshwater sources, and boiling water that is used for ablution17. Chlorine disinfection regimens prevent against most pathogens in drinking water systems however free living amoeba like N. Fowleri survive most disinfection. The cyst form of N. Fowleri is resistant to most disinfection and are associated with biofilm that can build up in drinking water systems. N. Fowleri have been isolated in drinking water systems in Australia, the United States and Pakistan, in both Australia and the United States they maintain chlorine levels of 0.5mg/L at all times in the drinking water18.To test the amount of chlorine needed to eliminate N. Fowleri, researchers conducted an experiment using two separate sites, a pre re-chlorination site and a post re-chlorination site, both sites were monitored before and after re-chlorination for a year. The results were that after chlorination of greater than 1mg/L at each site, in the post re-chlorination site the amoeba were gone within 60 days. The pre re-chlorination site would have seasonal flares of N.Fowleri but the c hlorine levels eliminated the protozoan and prevented further spread. Overall chlorine levels above 1mg/L result in the elimination of N.Fowleri in drinking water systems18. Summary of current areas of research notes: N. Fowleri is a rare pathogen that was discovered over fifty years ago. Since its discovery still not much is known about this pathogen. Future research into this pathogen will focus on patient complaint diagnosis and treatment, expanding the drugs that are used, biomarkers, and drug targets. In order to determine whether the patient has contracted PAM due to N.Fowleri the patients csf is tested and if the test is negative for bacterial cultures and the patient has a history of swimming or other aquatic activities, then the patient tests positive for N.Fowleri. Extracting csf can increase the pressure in the patients brain and lead to herniation of the brain. Because N. Fowleri travels to the brain via the nasal passage, the proposed route of diagnosis is collecting a nasal sample. Research confirms that N.Fowleri can be collected in both csf and nasal cultures3. Drugs administered through the nasal cavity, through the transcribial route would be delivered across the cribifrom plate to the inferior portion of the frontal lobe. This is the site where N. Fowleri attacks and spreads to the central nervous system. Drugs like amphotericin B do not decrease the minimum inhibitory concentration (mic) when administered intravenously. By potentially administering the drug transcribialy, the drug passes the blood barrier which would allow the drug to be more potent, trail the route of N.Fowleri, attack the site of infection, allow the lethal dose of drug to achieve the mic without venous drainage, and lastly to avoid symptoms of intravenous drug administration 15. There are clinically approved drugs that have promising amoebicidal effects. These drugs interrupt the mechanisms and processes of the amoeba. Digoxin and proyclidine both exhibit amoebicidal properties. Digoxin treats atrial fibrillation and heart rhythm disorder by helping the heart beat stronger and with more rhythm19. Proyclidine is used to treat Parkinsons and other diseases that cause involuntary muscle movement20. In order for further testing of the amoebicidal effects of these drugs to continue to be studied more drugs that have the potential to be amoebicidal must be identified and screened for tests to go from in vitro testing to in vivo testing. There has not been a lot of emphasis on finding drugs that treat N. Fowleri because the condition is rare and affects populations in the developing world. Biomarkers for PAM have been challenging to identify because little is known about N. Fowleris pathophysiology. Mass spectrometry, NMR and other tools of analysis are being utilized to identify biomarkers. Researchers are also making biochemical profiles of individuals in populations that contracted the disease against those who did not. These profiles will include information on the individuals age, gender, ethnicity and factors that predispose them to this condition3. This condition is rare and because of its rarity has been studied infrequently. With limited time and resources N.Fowleri is funded and studied less frequently than conditions that affect larger populations like Malaria or the Zika virus. The range of drugs used to treat patients with PAM is severely limited, researchers are developing drugs that would inhibit different processes of N.Fowleri. The drug pathways are hydrolytic enzymes that invade the host cells, glycocytic enzymes that are expressed differently by the pathogen, thiol based redox metabolism pathway, oxidative stress pathway, trypanothione pathways, and encystation and excystation pathways3. Bibliography 1. Naegleria fowleri- primary amebic meningoencephalitis (PAM) amebic encephalitis. Centers for Disease Control and Prevention Web site. =. Updated December 2015. Accessed January, 2017. 2. Martinez-Castillo M, Cardenas-Zuniga R, Coronado-Velazquez D, Debnath A, Serrano-Luna J, Shibayama M. Naegleria fowleri after 50 years: Is it a neglected pathogen? J Med Microbiol. 2016. doi: 10.1099/jmm.0.000303 [doi]. 3. Siddiqui R, Ali IKM, Cope JR, Khan NA. Biology and pathogenesis of naegleria fowleri. Acta Trop. 2016;164:375-394. doi: http://dx.doi.org/10.1016/j.actatropica.2016.09.009. 4. Coupat-Goutaland B, RÃ ©goudis E, Besseyrias M, et al. Population Structure in Naegleria fowleri as Revealed by Microsatellite Markers. Chiang T-Y, ed. PLoS ONE. 2016;11(4):e0152434. doi:10.1371/journal.pone.0152434. 5. The genome of naegleria gruberi illuminates early eukaryotic versatility. Cell. (- 5):- 631. doi: 10.1016/j.cell.2010.01.032. 6. Marciano-Cabral F, Cabral GA. The immune response to naegleria fowleri amebae and pathogenesis of infection. FEMS Immunology Medical Microbiology. 2007;51(2):243-259. doi: 10.1111/j.1574-695X.2007.00332.x. 7. Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 19.4, Cilia and Flagella: Structure and Movement. Available from: https://www.ncbi.nlm.nih.gov/books/NBK21698/ 8. Han, KL., Lee, HJ., Shin, M.H. et al. Parasitol Res (2004) 94: 53. doi:10.1007/s00436-004-1158-9 9. RÉVEILLER FL, SUH S, SULLIVAN K, CABANES P, MARCIANO-CABRAL F. Isolation of a unique membrane protein from naegleria fowleri. J Eukaryot Microbiol. 2001;48(6):676-682. doi: 10.1111/j.1550-7408.2001.tb00208.x. 10. Song, KJ., Song, KH., Kim, JH. et al. Parasitol Res (2008) 103: 313. doi:10.1007/s00436-008-0972-x 11. Cope JR, Ali IK. Primary amebic meningoencephalitis: What have we learned in the last 5 years? Curr Infect Dis Rep. 2016;18(10):31-016-0539-4. doi: 10.1007/s11908-016-0539-4 [doi]. 12. Baig AM, Khan NA. Tackling infection owing to brain-eating amoeba. Acta Trop. 2015;142:86-88. doi: 10.1016/j.actatropica.2014.11.004 [doi]. 13. Pugh JJ, Levy RA. Naegleria fowleri: Diagnosis, pathophysiology of brain inflammation, and antimicrobial treatments. ACS Chem Neurosci. 2016;7(9):1178-1179. doi: 10.1021/acschemneuro.6b00232 [doi]. 14. Heggie TW, KÃ ¼pper T. Surviving naegleria fowleri infections: A successful case report and novel therapeutic approach. Travel Medicine and Infectious Disease. . doi: http://dx.doi.org/10.1016/j.tmaid.2016.12.005. 15. Baig AM, Khan NA. Novel chemotherapeutic strategies in the management of primary amoebic meningoencephalitis due to naegleria fowleri. CNS Neuroscience Therapeutics. 2014;20(3):289-290. doi: 10.1111/cns.12225. 16. Jamieson A. Effect of clotrimazole on naegleria fowleri. J Clin Pathol. 1975;28(6):446-449. 17. Siddiqui R, Khan NA. Primary amoebic meningoencephalitis caused by naegleria fowleri: An old enemy presenting new challenges. PLoS Negl Trop Dis. 2014;8(8):e3017. doi: 10.1371/journal.pntd.0003017 [doi]. 18. Miller HC, Morgan MJ, Wylie JT, et al. Elimination of naegleria fowleri from bulk water and biofilm in an operational drinking water distribution system. Water Res. 2016;110:15-26. doi: S0043-1354(16)30912-5 [pii]. 19. Dawson AH, Buckley NA. Digoxin. Medicine. 2016;44(3):158-159. doi: http://dx.doi.org.proxy.campbell.edu/10.1016/j.mpmed.2015.12.006. 20. Procyclidine. Drugs.com Know more. Be sure Web site. https://www.drugs.com/cdi/procyclidine.htm. Updated 2017. Accessed 5/25/17, 2017. [1] Naegleria fowleri- primary amebic meningoencephalitis (PAM) amebic encephalitis. Centers for Disease Control and Prevention Web site. https://www.cdc.gov/parasites/naegleria/pathogen.html#history. Updated December 2015. Accessed January, 2017

Shc34 – 2.1, 2.2 & 2.3

SHC34 – 2. 1, 2. 2 & 2. 3 Potential dilemma 1 – If a child in the setting is using their own language, religion and customs due to wishes of parents/family. Why is this a dilemma? This is a dilemma as the practitioners at the setting my not be able to understand the child, this means they will struggle to teach the child and help them develop. If the parent does not want the child to learn English it may be a problem, most of the school/setting will be speaking English.The parent may feel they are not focussing enough on this certain child's religion and also, since the child is using their own customs they may find some of ours offensive. The difficulty between my duty of care and the rights of the child – A practitioner would have a duty of care to educate the child and help them develop. The child has a right to use their own language, religion and customs of family or group, this means the practitioner could not stop the child from getting an education becaus e of their language, religion and customs, they have a right to this.Also, linking to this, the child has a right to an education, meaning you would have to provide this to the child under any circumstances. How would I deal with this situation? First of all, I would try to compromise with the parent, that the child could possibly speak English in the setting and speak their own language at home. Explain to the parent this may affect their holistic development and exactly what it will affect and how. This may be too big of a compromise, so if not I would look into getting a translator into the setting to help the child develop and learn.What could be the risks for the child? The risk here for the child is that they may not develop fully. This would be their holistic development as they will not be able to understand the practitioner when they are explaining activities and work. They will not be socialising and they may get frustrated and feel alone in the setting. Potential Dilemma 2 – If a member of the family turns up to pick a child up, one that is not supposed to due to wishes of parents/family. I will use mother as an example in this dilemma, if a mother is not allowed contact with the child. Why is this a dilemma?There is a risk of upsetting the child if they see the mother which really shouldn't happen as they should not be let in, although sometimes there could be a situation where the mother is forceful. The family member who has asked for the mother not to see the child could be upset by this, as it was against their wishes for the mother to try to contact them. The difficulty between my duty of care and the rights of the child – A practitioner would have a duty of care to protect the child, keep them safe and there had to be a reason for them not being allowed contact, they should also respect the parents/family's wishes.According to the UNCRC the child has a right for their family to be together, this means the child would normally ha ve a right to see a member of their family, but in this situation it is best not to go against the familys wishes despite that right. How would I deal with this situation? I would deal with this situation by letting the mother know that she is not permitted to enter the setting. I would explain there was no possible way she could take the child as there are certain people who are allowed to pick every child up and she is not down as one.I would ask the mother to leave the setting and if it did turn into a forceful situation I would call another member of staff to help escort this person out. If we could not get the parent to leave we would have to involve the authorities. What could be the risks for the child? The risks for this child could be a variety of different things. Without knowing the mothers background we couldn't say any specific risk as the mother could be dangerous or it could be other reasons.If the child see's this person they may get confused, they may not even recog nise them but if they do it may confuse them as they are not permanent in their life. Potential dilemma 3 – If you think a child in the setting may have a special educational need but the parent does not want them referred to find out as they do not believe the child has a special educational need. Why is this a dilemma? This is a dilemma as the child may not be able to develop properly if it is not clear if they do need extra support.They will also be sure how much support and what kind of support they need by finding out what special educational need they have. The difficulty between my duty of care and the rights of the child – As a practitioner I have a duty of care to make sure the child is developing as they should, I should be making sure the child is reaching their full potential. I would also have to respect the parents wishes. Every child with special needs should have special care and support, if the parent rejects this idea it will be very difficult to get support. How would I deal with this situation?I would try to explain to the parent how it would benefit the child to even talk to someone about their special educational need. I would explain as best I could that this was important for the child but I could also arrange something with the SENCO so they had all the information they needed to make the desicion. What could be the risks for the child? The risks in this dilemma for the child would be that they may not be developing hollistically, they would need extra support that they are not getting. This could affect the child later in life too as they may struggle in their education as they get older.It is always best to identify a special educational need at the earliest possible point as this benefits the child, they may start lacking in all area's of development the later it is left. Where to get support and advice – For certain situations it means different people to contact for support. SENCO, your manager, child protecti on officer, social services etc. These are a few people you could go to when conflicts or dilemma's arise as they may be able to support or advise you. They may be able to work beside you to get the best outome for the child and support/advise you throughout it. Danielle Le Vesconte 30105251 1578571749

Top Safety Patrol Essay Samples Guide!

Top Safety Patrol Essay Samples Guide! The Fight Against Safety Patrol Essay Samples Various courses of action is going to be taken dependent on the degree of threat involved. An improved safety training regime requires employees involved with blasting to wear an indicator showing their existing amount of training on their hard hat in any respect times. All this is based off of the very first program that was made by the Congress in 1968. Students and staff should be offered with training on how best to respond to a pure disaster. What's Really Happening with Safety Patrol Essay Samples They change lots of things to produce the ship stronger and more efficient. Every security worker utilizes some type of prop or tool. You never know who you are receiving in the auto with,'' Norred explained. The exact same applies to all mechanical facets of the aircraft, and satellite navigation systems, landing gear and a lot more. Hence it becomes quite important that everybody should strictly comply with the traffic rules and ought to always drive safely with respecting the other people and vehicles on the street. Most importantly, there's a demand for us to be worried about our own safety and conduct whilst using the road. In practice an individual can actually discover that there's no such thing as absolute safety. For example fire alarm drills are performed in most organizations in order to make sure that folks understand how to respond in the event of a fire. New Questions About Safety Patrol Essay Samples To assist you do that, here are a couple of tips. The secret to the success of a security and wellness program is to see it like part of the company operation and to see it reflected in the day-to-day operations. There are a number of education and certification bodies accountable for providing safety certificates, so it is necessary to choose which institution to attend to find the training. A security management plan comprises the general security procedures that are relevant to a firm. As a way to understand safety management, an individual must first demystify the notion of safety. Ensuring road safety is vital and have to be prioritized by the governments and individuals. To summarize, a perfect safety management system would incorporate a management program and safety promotion. Developing a security certificate from scratch isn't easy. A procedure is also like building a document, there's a step-by-step process regarding how you should format it. There's an application procedure that demands the student to compose a brief paragraph describing why they'd love to be on the team and obtain their parent's approval. Scanning The major idea behind scanning is to recognize the issue. The sample of school security plans included here is meant to provide you with an overall idea of strategies that could be implemented to shield students, teachers, and visitors ali ke. Furthermore, the write-up discusses the use of civilians in the procedure for preventing crime, which lowers the burden on the traditional police patrol. Safety can just be defined as a circumstance where there isn't any harm or danger. A statement about the school's social and cultural atmosphere. Conclusion Traffic accidents are a main cause of deaths in India and it has affected an enormous number of families. Accordingly, in conclusion, police patrols ought to be continued, and ought to be supported by communities if they are supposed to continue to properly function. Why Almost Everything You've Learned About Safety Patrol Essay Samples Is Wrong Just comply with the guidelines stated above, and you will be well on your way to writing an excellent persuasive essay. The value of research in persuasive writing cannot be overstated. You still must make an outstanding bit of writing. Keep reading to learn. Even when you're not likely to compose a paper about it, you may as well opt for a topic from the list of persuasive essay topics above that for sure will be great for you. Evidently, you ought not purposely choose a topic that will bore your audience. When you settle on the subject and select the position on which you will base your essay, the remainder of the job can then begin. Possessing great research abilities and selecting an excellent topic is important.